W   21 - 10 

ESPN's College GameDay was in State College for the Saturday night Big Ten opener. The Hawkeyes fell behind early, 10-0. But Iowa would score 21 unanswered points after that to stun Penn State for the second consecutive year. The defense shut down the Nittany Lions in the final three quarters, forcing four turnovers, and the turning point in the game came when Penn State punted, clinging to a 10-5 lead in the fourth quarter, Adrian Clayborn blocked a punt and ran it back 53 yards for a touchdown to give the Hawkeyes the lead. With the momentum changed, they were more easily able to move the ball on their final two drives. The win at Penn State on prime-time network television catapulted Iowa to a number 13 ranking in the AP Poll and a number 17 ranking in the Coaches' Poll.

	1	2	3	4	F
Iowa	0	5	0	16	21
Penn State	10	0	0	0	10