W     41 - 7 

Henry L. Williams, the coach of the Gophers and Hall of Fame inductee in the inaugural class in 1951, was in his final year at Minnesota, having coached the Gophers to a 136–31–11 record from 1900 to 1921. The Hawkeyes handed Minnesota their worst loss under Williams and their second-worst loss ever, winning 41–7. It was the most points the Gophers had ever allowed in forty years of varsity football. Aubrey Devine had his best game of the season, scoring twenty-nine points and passing for the other twelve points. Devine rushed for four touchdowns, passed for two touchdowns and kicked five extra points. He had 484 total yards: 162 rushing yards, 122 passing yards and 200 return yards on kicks, punts and interceptions.

	1	2	3	4	F
Iowa	7	7	14	13	41
Minnesota	0	0	0	7	7